Article
A General Synthesis of Bis-indolylpiperazine-2,5-diones
Molecules
Document Type
Article
Publication Date
1-1-2012
DOI
10.3390/molecules171214841
Disciplines
Abstract
The one-pot synthesis of three dragmacidin derivatives is reported. Sarcosine anhydride (4) is brominated and immediately reacted with the corresponding indole to produce the products, namely 3,6-bis(5′-methoxy-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (1), 3,6-bis(7′-methyl-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (2) and 3,6-bis-(6′-chloro-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (3), which are characterized by 1H-NMR.
Copyright
© 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). Article obtained from Molbank, an open access journal.
Citation Information
Stephen N. Crooke and Christine Whitlock. "A General Synthesis of Bis-indolylpiperazine-2,5-diones" Molecules Vol. 17 Iss. 12 (2012) p. 14841 - 14845 ISSN: 1420-3049 Available at: http://works.bepress.com/christine_whitlock/14/
Article obtained from Molecules, an open access journal.