Skip to main content
Article
Chlamydia pneumoniae infection alters the junctional complex proteins of human brain microvascular endothelial cells
FEMS microbiology letters
  • Angela MacIntyre
  • Christine J. Hammond, Philadelphia College of Osteopathic Medicine
  • C. Scott Little, Philadelphia College of Osteopathic Medicine
  • Denah M. Appelt, Philadelphia College of Osteopathic Medicine
  • Brian J. Balin, Philadelphia College of Osteopathic Medicine
Document Type
Article
Publication Date
1-1-2002
Abstract
Chlamydia pneumoniae has been identified and associated with multiple sclerosis (MS) and Alzheimer's disease (AD) pathogenesis, although the relationship of this organism in these diseases remains controversial. We have hypothesized that one potential avenue of infection is through the junctional complexes between the blood-brain barrier (BBB) endothelia. C. pneumoniae is characteristically a respiratory pathogen, but has been implicated in atherosclerosis, coronary artery disease, and neuroinflammatory conditions. C. pneumoniae infection may lead to endothelial damage, junctional alterations, and BBB breakdown. Therefore, in this study, C. pneumoniae infection of human brain microvascular endothelial cells (HBMECs) resulted in increased expression of the zonula adherens proteins ß-catenin, N-cadherin, and VE-cadherin, and decreased expression of the tight junctional protein occludin, as determined by immunocytochemistry and Western blot analyses. These events may underlie a mechanism for the regulation of paracellular permeability while maintaining barrier integrity during C. pneumoniae infection associated with neuropathologies such as MS and AD.
Comments

This article was published in FEMS microbiology letters, Volume 217, Issue 2, Pages 167-172.

The published version is available at http://dx.doi.org/10.1016/S0378-1097(02)01066-2.

Copyright © 2002 FEMS.

Citation Information
Angela MacIntyre, Christine J. Hammond, C. Scott Little, Denah M. Appelt, et al.. "Chlamydia pneumoniae infection alters the junctional complex proteins of human brain microvascular endothelial cells" FEMS microbiology letters Vol. 217 Iss. 2 (2002) p. 167 - 172
Available at: http://works.bepress.com/christine_hammond/16/