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Article
Chlamydia pneumoniae infection promotes the transmigration of monocytes through human brain endothelial cells
Journal of neuroscience research
  • Angela MacIntyre
  • R. Abramov
  • Christine J. Hammond, Philadelphia College of Osteopathic Medicine
  • A. P. Hudson
  • E. J. Arking
  • C. Scott Little, Philadelphia College of Osteopathic Medicine
  • Denah M. Appelt, Philadelphia College of Osteopathic Medicine
  • Brian J. Balin, Philadelphia College of Osteopathic Medicine
Document Type
Article
Publication Date
1-1-2003
Abstract
We have investigated the effects of Chlamydia pneumoniae on human brain endothelial cells (HBMECs) and human monocytes as a mechanism for breaching the blood-brain barrier (BBB) in Alzheimer's disease (AD). HBMECs and peripheral blood monocytes may be key components in controlling the entry of C. pneumoniae into the human brain. Our results indicate that C. pneumoniae infects blood vessels and monocytes in AD brain tissues compared with normal brain tissue. C. pneumoniae infection stimulates transendothelial entry of monocytes through HBMECs. This entry is facilitated by the up-regulation of VCAM-1 and ICAM-1 on HBMECs and a corresponding increase of LFA-1, VLA-4, and MAC-1 on monocytes. C. pneumoniae infection in HBMECs and THP-1 monocytes up-regulates monocyte transmigration threefold in an in vitro brain endothelial monolayer. In this way, C. pneumoniae infection in these cell types may contribute to increased monocyte migration and promote inflammation within the CNS resulting from infection at the level of the vasculature. Thus, infection at the level of the vasculature may be a key initiating factor in the pathogenesis of neurodegenerative diseases such as sporadic AD.
Comments

This article was published in Journal of neuroscience research, Volume 71, Issue 5, Pages 740-750.

The published version is available at http://dx.doi.org/10.1002/jnr.10519.

Copyright © 2003 Wiley.

Citation Information
Angela MacIntyre, R. Abramov, Christine J. Hammond, A. P. Hudson, et al.. "Chlamydia pneumoniae infection promotes the transmigration of monocytes through human brain endothelial cells" Journal of neuroscience research Vol. 71 Iss. 5 (2003) p. 740 - 750
Available at: http://works.bepress.com/christine_hammond/15/