J. Edward and Helen M. C. Stern Endowed Professorship in Neuroscience
Our laboratory studies brain and behavior during development. In child studies, we examine cognitive sequelae of genetic variants and medical conditions. Genetic variants and medical conditions with known cognitive sequelae provide a natural manipulation of brain mechanisms that may be unrecognized as critical for key mental functions, such as visual attention, working memory, inhibitory control, and motor dexterity. Our work is translational and we use results from child studies to guide the development of new animal models.
Currently, we are studying the effects on brain and behavior of early chronic low-level lead exposure. In child studies, we have provided new evidence of a genetic variant (hPEPT2) that increases low blood lead burden and predicts unique motor and memory deficits in young low-level lead exposed males. In mouse lead exposure studies, we have identified memory deficits using a novel odor recognition task and quantified loss of microglia in dentate gyrus following early chronic low-level lead exposure. In future studies we will test these effects in a transgenic mouse model.
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Currently, we are studying the effects on brain and behavior of early chronic low-level lead exposure. In child studies, we have provided new evidence of a genetic variant (hPEPT2) that increases low blood lead burden and predicts unique motor and memory deficits in young low-level lead exposed males. In mouse lead exposure studies, we have identified memory deficits using a novel odor recognition task and quantified loss of microglia in dentate gyrus following early chronic low-level lead exposure. In future studies we will test these effects in a transgenic mouse model.
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About Christina Sobin, Ph.D.
Our laboratory studies brain and behavior during development. In child studies, we examine cognitive sequelae of genetic variants and medical conditions. Genetic variants and medical conditions with known cognitive sequelae provide a natural manipulation of brain mechanisms that may be unrecognized as critical for key mental functions, such as visual attention, working memory, inhibitory control, and motor dexterity. Our work is translational and we use results from child studies to guide the development of new animal models.
Currently, we are studying the effects on brain and behavior of early chronic low-level lead exposure. In child studies, we have provided new evidence of a genetic variant (hPEPT2) that increases low blood lead burden and predicts unique motor and memory deficits in young low-level lead exposed males. In mouse lead exposure studies, we have identified memory deficits using a novel odor recognition task and quantified loss of microglia in dentate gyrus following early chronic low-level lead exposure. In future studies we will test these effects in a transgenic mouse model.
Currently, we are studying the effects on brain and behavior of early chronic low-level lead exposure. In child studies, we have provided new evidence of a genetic variant (hPEPT2) that increases low blood lead burden and predicts unique motor and memory deficits in young low-level lead exposed males. In mouse lead exposure studies, we have identified memory deficits using a novel odor recognition task and quantified loss of microglia in dentate gyrus following early chronic low-level lead exposure. In future studies we will test these effects in a transgenic mouse model.
| Present | Adjunct Faculty, Laboratory of Neuroendocrinology, The Rockefeller University, NY, NY | |
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| Present | Associate Professor, Public Health Sciences, College of Health Sciences, University of Texas at El Paso | |
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| Present | J. Edward and Helen M. C. Stern Endowed Professorship in Neuroscience, University of Texas at El Paso | |
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Disciplines
Research Interests
Honors and Awards
- J. Edward and Helen M. C. Stern Professorship in Neuroscience
Courses
- Experimental Methods and Design
- Statistics
- Scientific Writing
Contact Information
Laboratory of Developmental Neurocognition
University of Texas in El Paso
500 West University
El Paso, Texas 79968
PHONE: 915-747-8485
Email: