This study reports data comparing Five Factor Model (FFM) facets with the Inventory of Children’s Individual Differences–Short Form (ICID-S) in children with an autism spectrum disorder (ASD) during middle childhood with same-age typically developing children. Two (ASD vs. Typical) × 2 (Sex) age-controlled MANCOVAs were performed: (a) ASD versus a contemporaneous comparison group and (b) ASD versus a norming data subset. Significant gender interactions are reported for the Agreeableness, Neuroticism, and Extraversion facets. Most FFM facets in the ASD group were reliable, and group differences in both analyses were consistent with the broader ASD literature. Contemporary and normative analyses resulted in very similar significant differences and effect sizes.