This study reports data indicating that the Five Factor facets measured with the Inventory of Children’s Individual Differences- Short Form (ICID-S; Deal, Halverson, Martin, Victor, & Baker, Journal of Personality Assessment, 89, 162–166, 2007) differentiate children with an autism spectrum disorder (ASD) from typically developing children during early childhood. Two 2 (ASD versus typical) by 2 (Sex) age controlled MANCOVAs were performed: (1) ASD versus a contemporaneous comparison group and (2) ASD versus a norming data subset. Socio-economic status was also controlled in the contemporaneous comparison. Results indicated that group differences in both analyses were consistent with the broader ASD literature.