Thinking outside the nucleus: mitochondrial DNA copy number in health and diseaseScienceDirect (2020)
Mitochondrial DNA copy number (mtDNA-CN) is a biomarker of mitochondrial function and levels of mtDNA-CN have been reproducibly associated with overall mortality and a number of age-related diseases, including cardiovascular disease, chronic kidney disease, and cancer. Recent advancements in techniques for estimating mtDNA-CN, in particular the use of DNA microarrays and next-generation sequencing data, have led to the comprehensive assessment of mtDNA-CN across these and other diseases and traits. The importance of mtDNA-CN measures to disease and these advancing technologies suggest the potential for mtDNA-CN to be a useful biomarker in the clinic. While the exact mechanism(s) underlying the association of mtDNA-CN with disease remain to be elucidated, we review the existing literature which supports roles for inflammatory dynamics, immune function and alterations to cell signaling as consequences of variation in mtDNA-CN. We propose that future studies should focus on characterizing longitudinal, cell-type and cross-tissue profiles of mtDNA-CN as well as improving methods for measuring mtDNA-CN which will expand the potential for its use as a clinical biomarker.
- Cardiovascular disease
Publication DateSpring March 14, 2020
Citation InformationChristina Castellani, Ryan J Longchamps, Jing Sun, Eliseo Guallar, et al.. "Thinking outside the nucleus: mitochondrial DNA copy number in health and disease" ScienceDirect Vol. 53 (2020) p. 214 - 223
Available at: http://works.bepress.com/christina-castellani/2/