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Unpublished Paper
Membrane Fluctuations Around Inclusions
Scientific Modeling and Simulation (2007)
  • Christian Santangelo
  • Oded Farago

The free energy of inserting a protein into a membrane is determined by considering the variation in the spectrum of thermal fluctuations in response to the presence of a rigid inclusion. Both numerically and through a simple analytical approximation, we find that the primary effect of fluctuations is to reduce the effective surface tension, hampering the insertion at low surface tension. Our results, which should also be relevant for membrane pores, suggest (in contrast to classical nucleation theory) that a finite surface tension is necessary to facilitate the opening of a pore.

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Citation Information
Christian Santangelo and Oded Farago. "Membrane Fluctuations Around Inclusions" Scientific Modeling and Simulation (2007)
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