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Kidney disease and organ transplantation in methylmalonic acidaemia.
Pediatric Transplantation
  • Damien Noone
  • Magdalena Riedl
  • Paul Atkison, Western University
  • Yaron Avitzur
  • Ajay P Sharma, Western University
  • Guido Filler, Western University
  • Komudi Siriwardena
  • Chitra Prasad, Western University
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MMA is associated with chronic tubulointerstitial nephritis and a progressive decline in GFR. Optimal management of these children is uncertain. Our objectives were to document the pre-, peri-, and post-transplant course of all children with MMA who underwent liver or combined liver-kidney transplant in our centers.

Retrospective chart review of all cases of MMA who underwent organ transplantation over the last 10 years.

RESULTS: Five children with MMA underwent liver transplant (4/5) and combined liver-kidney transplant (1/5). Three were Mut

MMA is a complex metabolic disorder. Renal disease can continue to progress post-liver transplant and close follow-up is warranted. More research is needed to clarify best screening GFR method in patients with MMA. Whether liver transplant alone, continued protein restriction, or the addition of antioxidants post-transplant can halt the progression of renal disease remains unclear.

Citation Information
Damien Noone, Magdalena Riedl, Paul Atkison, Yaron Avitzur, et al.. "Kidney disease and organ transplantation in methylmalonic acidaemia." Pediatric Transplantation Vol. 23 Iss. 4 (2019) p. 13407 - 13407
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