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Article
A single-center, pilot study evaluating a novel TriHex peptide- and botanical-containing eye treatment compared to baseline.
J Cosmet Dermatol
  • Alex Reivitis, Providence St. John's Health Center, Los Angeles, CA, USA
  • Kian Karimi, Providence St. John's Health Center, Los Angeles, CA, USA
  • Chester Griffiths, Providence St. John's Health Center, Los Angeles, CA, USA
  • Ashley Banayan, Providence St. John's Health Center, Los Angeles, CA, USA
Document Type
Article
Publication Date
6-1-2018
Keywords
  • anti-aging,
  • elastin,
  • extracellular matrix disruption,
  • eyelid,
  • hexapeptide,
  • tripeptide,
  • Adult,
  • Eye,
  • Female,
  • Humans,
  • Male,
  • Middle Aged,
  • Peptides/therapeutic use,
  • Pilot Projects,
  • Plant Preparations/therapeutic use,
  • Skin Aging/drug effects
Disciplines
Abstract

BACKGROUND: Topical treatments containing tripeptide and hexapeptide (TriHex technology) have been proven to contribute to youthful skin by clearing the extracellular matrix and stimulating collagen and elastin production.

OBJECTIVE: Evaluate the efficacy of a novel eye treatment containing TriHex peptides and other synergistic ingredients for the daily treatment of fine lines/crow's feet around the eyes, under eye hollowing, under eye bags, and dark circles.

PATIENTS/METHODS: In this study, 10 subjects (9 female and 1 male) aged 30-60 of Fitzpatrick skin type I, II, or III were selected to use an eye treatment containing TriHex peptides and active botanicals (Alastin Restorative Eye Treatment with TriHex Technology™, ALASTIN Skincare, Inc., Carlsbad, CA) twice daily for 12 weeks. Subjects were photographed and evaluated at baseline, week 4, week 8, and week 12 by a board-certified facial plastic surgeon. Using an adjusted Griffiths scale (0 = none, best possible condition and 9 = severe, worst possible condition), subjects were evaluated on severity of fine lines/crow's feet, under eye hollowing, under eye bags, and dark circles at each visit. Subjects completed a "Subject Questionnaire" at week 4, week 8, and week 12 pertaining to the subject's observations and perceived improvement of these measures.

RESULTS: Based on the investigator's assessments, overall improvement in periocular skin was noted for all 10 subjects. Over the course of 12 weeks, raw scores significantly decreased indicating reduction of lines/crow's feet (41% improvement), under eye hollowing (29% improvement), under eye bags (48% improvement), and dark circles (39% improvement). Based on the "Subject Questionnaire," all subjects noted overall improvement of the appearance of skin around the eyes.

CONCLUSION: Based on the findings of this study, this eye treatment containing TriHex peptides and active botanicals is an effective stand-alone treatment for the rejuvenation of periocular skin. When used twice daily, this product can reduce the appearance of lines/crow's feet, under eye hollowing, under eye bags, and dark circles.

Department
Dermatology
Citation Information
Alex Reivitis, Kian Karimi, Chester Griffiths and Ashley Banayan. "A single-center, pilot study evaluating a novel TriHex peptide- and botanical-containing eye treatment compared to baseline." J Cosmet Dermatol (2018)
Available at: http://works.bepress.com/chester-griffiths/169/