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Normative salivary cortisol values and responsivity in children
Applied Nursing Research
  • Ann Marie McCarthy, University of Iowa
  • KIrsten M. Hanrahan, University of Iowa
  • Charmaine Kleiber, University of Iowa
  • M. B. Zimmerman
  • S. Lutgendorf
  • E. Tsalikian
Document Type
Peer Reviewed
Publication Date
NLM Title Abbreviation
Appl Nurs Res
PubMed ID
DOI of Published Version
This was a descriptive study on normative salivary cortisol values and responsivity to a hospital clinic visit and an intravenous (IV) procedure in children. The study presented was a subproject of a primary research study that examined parents coaching their children requiring an IV placement in the use of distraction. One measure of child response in the primary study, salivary cortisol, was included to further our understanding of children's physiologic response to stressful and painful stimuli. Salivary cortisol samples were obtained from 384 children aged between 4 and 10 years upon arrival to the clinic and 20 minutes after their IV insertion. Baseline samples were collected at home on a typical day for the children. Data from baseline samples were used to establish normative values between 8:00 a.m. and 3:00 p.m. on a nonprocedural day. Results demonstrate that normative cortisol levels in children follow a pattern similar to the circadian pattern in adults, decreasing from early morning to mid afternoon. Matched samples from control group children were used to evaluate group responsivity. Salivary cortisol levels on the baseline day were lower than those obtained during the day of the procedure and tapered over time as expected (-8.7% +/- 6.7%, p = .431). Cortisol levels on the clinic day increased from baseline and increased further in response to IV placement (15.7% +/- 6.7%, p = .023). A Location x Time interaction was significant (p = .019). Findings demonstrate that salivary cortisol is a useful measure of stress response that can be used to evaluate intervention effectiveness.
  • Child,
  • Child,
  • Preschool,
  • Circadian Rhythm,
  • Humans,
  • Hydrocortisone/analysis,
  • Quality Control,
  • Saliva/chemistry
Published Article/Book Citation
Applied Nursing Research, 22:1 (2009) pp.54-62. DOI:10.1016/j.apnr.2007.04.009.
Citation Information
Ann Marie McCarthy, KIrsten M. Hanrahan, Charmaine Kleiber, M. B. Zimmerman, et al.. "Normative salivary cortisol values and responsivity in children" Applied Nursing Research Vol. 22 Iss. 1 (2009) p. 54 - 62 ISSN: 1532-8201
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