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Saline for peripheral intravenous locks in neonates: evaluating a change in practice
Neonatal network
  • KIrsten M. Hanrahan, University of Iowa
  • Charmaine Kleiber, University of Iowa
  • S. Berends
Document Type
Peer Reviewed
Publication Date
NLM Title Abbreviation
Neonatal Netw
PubMed ID
PURPOSE: To evaluate the efficacy of saline versus 10 units/ml heparin for peripheral i.v. flushes in neonates. DESIGN: A nonexperimental group design was used to compare the longevity of heparin and saline i.v. locks. A research utilization method was chosen to increase the study power while simultaneously implementing a practice change and evaluating the outcomes. Power analysis showed that a sample size of approximately 120 per group was needed to decrease the risk of beta error to 0.1. SAMPLE: Subjects included neonates in the Special Care Nurseries at a Level III large midwestern university teaching hospital. Data were collected from a convenience sample of 123 neonates receiving 10 units/ml heparin flush into a peripheral i.v. Practice was then changed to preservative-free normal saline, and data collection continued for 117 neonates. MAIN OUTCOME VARIABLE: I.v. catheter longevity. RESULTS: There was no significant statistical difference in i.v. catheter longevity between i.v. locks flushed with 10 units/ml heparin and those flushed with normal saline. Patient weight accounted for a significant proportion of the variance in i.v. catheter life.
  • Catheterization,
  • Peripheral/adverse effects/methods,
  • Evaluation Studies as Topic,
  • Female,
  • Heparin/pharmacology,
  • Humans,
  • Infant,
  • Newborn,
  • Infusions,
  • Intravenous/nursing,
  • Intensive Care Units,
  • Neonatal,
  • Male,
  • Monitoring,
  • Physiologic/nursing,
  • Neonatal Nursing/methods,
  • Probability,
  • Prospective Studies,
  • Reference Values,
  • Sensitivity and Specificity,
  • Sodium Chloride/pharmacology
Published Article/Book Citation
Neonatal network, 19:2 (2000) pp.19-24.
Citation Information
KIrsten M. Hanrahan, Charmaine Kleiber and S. Berends. "Saline for peripheral intravenous locks in neonates: evaluating a change in practice" Neonatal network Vol. 19 Iss. 2 (2000) p. 19 - 24 ISSN: 0730-0832
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