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Article
NASA Light-Emitting Diodes for the Prevention of Oral Mucositis in Pediatric Bone Marrow Transplant Patients
Journal of Clinical Laser Medicine & Surgery
  • Harry T. Whelan, Medical College of Wisconsin
  • James F. Connelly, Medical College of Wisconsin
  • Brian D. Hodgson, Marquette University
  • Lori Barbeau, Children's Hospital of Wisconsin
  • A. Charles Post, Children's Hospital of Wisconsin
  • George Bullard, Children's Hospital of Wisconsin
  • Ellen V. Buchmann, Medical College of Wisconsin
  • Mary Kane, Medical College of Wisconsin
  • Noel T. Whelan, Medical College of Wisconsin
  • Ann Warwick, Medical College of Wisconsin
  • David Margolis, Medical College of Wisconsin
Document Type
Article
Language
eng
Format of Original
6 p.
Publication Date
12-1-2002
Publisher
Mary Ann Liebert Inc.
Original Item ID
doi: 10.1089/104454702320901107
Disciplines
Abstract
Objective: The purpose of this study was to determine the effects of prophylactic near-infrared light therapy from light-emitting diodes (LEDs) in pediatric bone marrow transplant (BMT) recipients. Background Data: Oral mucositis (OM) is a frequent side effect of chemotherapy that leads to increased morbidity. Near-infrared light has been shown to produce biostimulatory effects in tissues, and previous results using nearinfrared lasers have shown improvement in OM indices. However, LEDs may hold greater potential for clinical applications. Materials and Methods: We recruited 32 consecutive pediatric patients undergoing myeloablative therapy in preparation for BMT. Patients were examined by two of three pediatric dentists trained in assessing the Schubert oral mucositis index (OMI) for left and right buccal and lateral tongue mucosal surfaces, while the patients were asked to rate their current left and right mouth pain, left and right xerostomia, and throat pain. LED therapy consisted of daily treatment at a fluence of 4 J/cm2 using a 670-nm LED array held to the left extraoral epithelium starting on the day of transplant, with a concurrent sham treatment on the right. Patients were assessed before BMT and every 2–3 days through posttransplant day 14. Outcomes included the percentage of patients with ulcerative oral mucositis (UOM) compared to historical epidemiological controls, the comparison of left and right buccal pain to throat pain, and the comparison between sides of the buccal and lateral tongue OMI and buccal pain. Results: The incidence of UOM was 53%, compared to an expected rate of 70–90%. There was also a 48% and 39% reduction of treated left and right buccal pain, respectively, compared to untreated throat pain at about posttransplant day 7 (p < 0.05). There were no significant differences between sides in OMI or pain. Conclusion: Although more studies are needed, LED therapy appears useful in the prevention of OM in pediatric BMT patients.
Comments

Published version. Journal of Clinical Laser Medicine and Surgery, Volume 20, No. 6 (December 2002), DOI. Used with permission.

This is a copy of an article published in the Journal of Clinical Laser Medicine and Surgery © 2002 Mary Ann Liebert, Inc.; Journal of Clinical Laser Medicine and Surgery is available online at: http://www.liebertonline.com.

Brian Hodgson was affiliated with Children's Hospital of Wisconsin at the time of publication.

Citation Information
Harry T. Whelan, James F. Connelly, Brian D. Hodgson, Lori Barbeau, et al.. "NASA Light-Emitting Diodes for the Prevention of Oral Mucositis in Pediatric Bone Marrow Transplant Patients" Journal of Clinical Laser Medicine & Surgery (2002) ISSN: 1044-5471
Available at: http://works.bepress.com/charlie_post/50/