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Article
The Role of Capillaries in the Lesser Ailments of Old Age and in Alzheimer’s Disease and Vascular Dementia: The Potential of Pro-Therapeutic Angiogenesis
Journal of Alzheimer's Disease (2016)
  • Charles T. Ambrose, University of Kentucky
Abstract
Apart from chronic diseases (arthritis, diabetes, etc.), old age is generally characterized by three lesser ailments: muscle weakness, minor memory lapses, and cold intolerance. This trio of complaints may have a common, underlying cause, namely, the age-associated reduced microcirculation in muscles, brain, skin, and elsewhere in the body. The Angiogenesis Hypothesis proposes that old age is in part a deficiency disease due to the decline in angiogenic (AG) factors, resulting in a reduced capillary density (CD) throughout the body. Over fifty published papers document waning levels of AG factors and/or decreased CD in various organ systems of aged animals and people, including those with Alzheimer’s disease. The deficiency of AG factors is analogous to that of certain hormones (e.g., testosterone) whose blood levels also decline with age. In theory, therapeutic angiogenesis employing recombinant AG factors is a tenable treatment for the lesser ailments of old age and may improve the later years of human life. An optimal administration route may be intranasal.
Keywords
  • Aging,
  • Alzheimer’s disease,
  • angiogenesis,
  • capillary density,
  • cold intolerance,
  • memory lapses,
  • muscle weakness,
  • vascular dementia
Disciplines
Publication Date
2016
DOI
https://doi.org/10.3233/JAD-160303
Citation Information
Charles T. Ambrose. "The Role of Capillaries in the Lesser Ailments of Old Age and in Alzheimer’s Disease and Vascular Dementia: The Potential of Pro-Therapeutic Angiogenesis" Journal of Alzheimer's Disease Vol. 54 Iss. 1 (2016) p. 31 - 43
Available at: http://works.bepress.com/charles_ambrose/63/