The present study was an attempt to investigate hypotheses about the interrelationship of brain dysfunction and symptoms of schizophrenia using the Brief Psychiatric Rating Scale (BPRS) and a measure of cerebral ventricular size. The ventricular brain ratio (VBR) was correlated with admission and discharge scores on the BPRS in 46 schizophrenic patients. A significant relationship was found between VBR and discharge BPRS scores. In general, the results were partially supportive of relationships found between neuropsychological data and the BPRS in a previous study, but shed little light on the relationships between brain damage and negative and positive symptoms. Limitations of using the BPRS, as well as possible sampling variations, are discussed.