YouTube provides a mechanism through which video clips may be grouped into sharable online collections called playlists. A "video playlist lesson" is composed of a group of educational video clips and a lesson plan with one or more specific instructional objectives typed in the playlist description. Video playlist lessons can be mapped to established taxonomies within the cognitive, affective, and psychomotor learning domains to structure the lessons for different types of learning. This approach provides a systematic method through which instructional activities, measurable outcomes, and new media selection may be aligned. This paper describes the approach, which has been field-tested in multiple sections of an online graduate-level course that focuses on instructional applications of YouTube.