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Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase
Biochemical and Biophysical Research Communications (2006)
  • Chanin Nantasenamat
  • Chartchalerm Isarankura-Na-Ayudhya
  • Theeraphon Piacham
  • Sakda Yainoy
  • Lei Ye
  • Leif Bülow
  • Virapong Prachayasittikul
Abstract

Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of electrostatic charge of transition metal ions on the SOD activity. © 2006 Elsevier Inc. All rights reserved.

Keywords
  • Antibiotic,
  • Bacitracin,
  • Molecular modeling,
  • SOD,
  • SOD mimic,
  • Superoxide dismutase
Publication Date
2006
Citation Information
Chanin Nantasenamat, Chartchalerm Isarankura-Na-Ayudhya, Theeraphon Piacham, Sakda Yainoy, et al.. "Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase" Biochemical and Biophysical Research Communications Vol. 341 (2006)
Available at: http://works.bepress.com/chanin/5/