A simple, low-cost optofluidic sensor platform composed of ubiquitous materials is developed. The main device structure consists of an extremely simple assembly of readily available materials including metal wires and polymeric microbore tubing. We demonstrate that the quenching-based fluorescence oxygen sensing, as a model system, can be conducted with this cost-effective device platform. This 1-dimensional "lab-in-tube" configuration has a high potential for conducting a streamlined bioanalytical procedures, such as immunoassays including the enzyme-linked-immunosorbent assay (ELISA), with convenience for fluidic manipulation. Its potential capability includes surface-enhanced signals, multi-modality sensing and simultaneous/multiple assays. We anticipate the proposed device platform to make one of viable candidates for future point-of-care (POC) screening devices.