A 14-year-old male with bilateral above-the-knee amputations presented to our hospital for treatment of a skin and soft-tissue infection. We report the experience of vancomycin and gentamicin therapy in this patient. Because these medications require weight-based dosages and pharmacokinetic monitoring of serum levels, it was necessary to obtain peak and trough levels of the two drugs in order to determine the pharmacokinetic differences in this patient compared to those in an adolescent male without amputations. To our knowledge, this is the first report describing pharmacokinetic differences in an adolescent amputee.
This article was archived with permission from Pediatric Pharmacy Advocacy Group, all rights reserved. Document also available from Journal of Pediatric Pharmacology and Therapy.
Available at: http://works.bepress.com/chad_knoderer/22/