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Article
Vancomycin and Gentamicin Pharmacokinetic Alterations in an Adolescent Amputee
Journal of Pediatric Pharmacology and Therapy
  • Kristen R. Nichols, Butler University
  • Kari M. Edison
  • Michelle D. Rosenbaum
  • Chad A. Knoderer, Butler University
Document Type
Article
Publication Date
1-1-2013
DOI
http://dx.doi.org/10.5863/1551-6776-18.1.63
Abstract
A 14-year-old male with bilateral above-the-knee amputations presented to our hospital for treatment of a skin and soft-tissue infection. We report the experience of vancomycin and gentamicin therapy in this patient. Because these medications require weight-based dosages and pharmacokinetic monitoring of serum levels, it was necessary to obtain peak and trough levels of the two drugs in order to determine the pharmacokinetic differences in this patient compared to those in an adolescent male without amputations. To our knowledge, this is the first report describing pharmacokinetic differences in an adolescent amputee.
Rights

This article was archived with permission from Pediatric Pharmacy Advocacy Group, all rights reserved. Document also available from Journal of Pediatric Pharmacology and Therapy.

Citation Information
Kristen R. Nichols, Kari M. Edison, Michelle D. Rosenbaum and Chad A. Knoderer. "Vancomycin and Gentamicin Pharmacokinetic Alterations in an Adolescent Amputee" Journal of Pediatric Pharmacology and Therapy Vol. 18 Iss. 1 (2013) p. 63 - 66
Available at: http://works.bepress.com/chad_knoderer/22/