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A graph-theoretic model based on primary and predicted secondary structure reveals functional specificity in a set of plant secondary product UDP-glucosyltransferases
International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics 2009 (BCBGC-09) (2009)
  • Debra Knisley, East Tennessee State University
  • E. Seier
  • David Lamb
  • Daniel K. Owens, East Tennessee State University
  • Cecilia A. McIntosh, East Tennessee State University
Abstract
Plant secondary product glucosyltransferases (GTs), specifically flavonoid GTs, are being used as the model proteins. These GTs catalyze transfer of glucose from UDP-glucose to a wide variety of secondary metabolites. Although primary structure information is available for many putative GTs through genomic and proteomic databases, a direct biochemical link between structure and function exists for only subset of the proteins. In this work we utilize the primary sequences and predicted secondary structures of a set of GTs to build several graph-theoretic models of each GT. We determine graphical invariants and utilize them as descriptors of the biomolecules. Statistical analysis of the descriptors reveals additional information regarding substrate specificity. Copyright© (2009) by the International Society for Research in Science and Technology.
Publication Date
2009
Editor
W. Loging, M. Doble, Z. Sun, and J. Malone
Publisher
International Society for Research in Science and Technology ( ISRST ); Printed by Curran Associates, Inc.
ISBN
9781615676538
Publisher Statement
Proceedings of a meeting held 13-16 July 2009, Orlando, Florida, USA.
Copyright© (2009) by the International Society for Research in Science and Technology All rights reserved.
Citation Information
Knisley, D., Seier, E., Lamb, D., Owens, D. K., McIntosh, C. A. (2009). A graph-theoretic model based on primary and predicted secondary structure reveals functional specificity in a set of plant secondary product UDP-glucosyltransferases. In W. Loging, M. Doble, Z. Sun, and J. Malone (Eds.), International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics 2009 (BCBGC-09), Orlando, Florida, USA 13-16 July 2009 (pp. 65-72). Tallahassee, FL : International Society for Research in Science and Technology ; Red Hook, NY : Printed by Curran Associates, Inc. Retrieved from http://www.proceedings.com/06730.html