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Atrial form and function: Lessons from human molecular genetics
Trends in cardiovascular medicine
  • Cathy J. Hatcher, Philadelphia College of Osteopathic Medicine
  • Minsu Kim
  • Craig T. Basson
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Molecular genetic analyses of human hereditary disorders that affect cardiac atrial structure and function have recently identified several genes that regulate atrial morphogenesis. Mutations of the TBX5, NKX2.5, EVC, and PRKAR1α genes all result in abnormalities of human atrial growth and development, and mutations in at least one gene results in familial atrial fibrillation and is as yet unidentified. Ongoing studies to find interactions between these transcription factors and intracellular signaling molecules and other as yet unknown genes are establishing critical pathways in human cardiogenesis. Human investigation and experimental animal models of heart development synergize to elucidate etiologies of common congenital heart disease. Copyright © 2000 Elsevier Science Inc.


This article was published in Trends in cardiovascular medicine, Volume 10, Issue 3, Pages 93-101.

The published version is available at

Copyright © 2000 Elsevier.

Citation Information
Cathy J. Hatcher, Minsu Kim and Craig T. Basson. "Atrial form and function: Lessons from human molecular genetics" Trends in cardiovascular medicine Vol. 10 Iss. 3 (2000) p. 93 - 101
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