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Transcription factor cascades in congenital heart malformation
Trends in molecular medicine
  • Cathy J. Hatcher, Philadelphia College of Osteopathic Medicine
  • Nata Diman
  • Deborah A. McDermott
  • Craig T. Basson
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New observations reveal that GATA-4 mutations are one underlying cause of human cardiac septal defects. Recent data has shed light on a potential multiprotein complex formed by GATA-4, TBX5 and NKX2.5, which might act synergistically to transcriptionally regulate other cardiac specific genes. The addition of GATA-4 to the list of genes involved in human congenital heart malformation prompts consideration of how modern molecular genetic advances should be applied to clinical care.

This article was published in Trends in molecular medicine, Volume 9, Issue 12, Pages 512-515.

The published version is available at

Copyright © 2003 Elsevier.

Citation Information
Cathy J. Hatcher, Nata Diman, Deborah A. McDermott and Craig T. Basson. "Transcription factor cascades in congenital heart malformation" Trends in molecular medicine Vol. 9 Iss. 12 (2003) p. 512 - 515
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