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A review of the bioactivity of coffee, caffeine and key coffee constituents on inflammatory responses linked to depression
Food Research International
  • Susan Hall, Griffith University, Queensland, Australia
  • Ben Desbrow, Griffith University
  • Shailendra Anoopkumar-Dukie, Griffith University
  • Andrew K. Davey, Griffith University
  • Devindar Arora, Griffith University
  • Catherine M. McDermott, Bond University
  • Matthew Schubert, University of Kansas Medical Center, KS, USA
  • Anthony V. Perkins, Griffith University
  • Milton Kiefel, Griffith University
  • Gary D. Grant, Griffith University
Date of this Version
8-4-2015
Document Type
Journal Article
Publication Details

Citation only

Hall, S., Desbrow, B., Anoopkumar-Dukie, S., Davey, A. K., Arora, D., McDermott, C., Schubert, M., Perkins, A. V., Kiefel, M., & Grant, G. (2015). A review of the bioactivity of coffee, caffeine and key coffee constituents on inflammatory responses linked to depression. Food Research International, 76(3), 626-636.

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2015 HERDC submission

© Copyright, Elsevier, 2015

Abstract

Coffee is a widely consumed beverage containing numerous biologically active constituents predominantly belonging to the polyphenol and alkaloid classes. It has been established that coffee has a beneficial effect on numerous disease states including depression. A number of prospective and retrospective cohort studies have assessed the effects of coffee consumption on the relative risk of developing major depressive disorder in humans. These studies have identified an inverse relationship between the consumption of caffeinated coffee and the risk of developing depression. Caffeine, chlorogenic acid, ferulic acid and caffeic acid, all important constituents of coffee, have been shown to possess biological activities that highlight a possible mechanistic link to the pathology of depression. This review aims to assess the evidence from the biological evaluation of these constituents of coffee on markers of inflammation associated with depression in in vitro and in vivo models of inflammation, neuroinflammation and depression. The ability of bioactive coffee constituents to modulate the parameters of neuroinflammation has been shown with caffeine having strong antioxidant properties in vitro, chlorogenic acid and caffeic acid having strong anti-inflammatory and antioxidant properties in vitro and ferulic acid having activities in in vivo animal models of depression.

Citation Information
Susan Hall, Ben Desbrow, Shailendra Anoopkumar-Dukie, Andrew K. Davey, et al.. "A review of the bioactivity of coffee, caffeine and key coffee constituents on inflammatory responses linked to depression" Food Research International Vol. 76 Iss. 3 (2015) p. 626 - 636 ISSN: 1445-6354
Available at: http://works.bepress.com/catherine_mcdermott/17/