HIV infection is a common worldwide public health challenge affecting an estimated 40 million persons. In the United States, there have been over 900,000 cases of AIDS, and it is estimated that there are currently over 1 million HIV-infected persons in the United States. Although the population of HIV seropositivity is concentrated in large urban settings, infections have been documented in all states. Because of the widespread prevalence and serious health consequences, it is imperative that the emergency physician be knowledgeable and skilled to diagnose and manage HIV-related emergency conditions. Knowledge of clinical presentations, differential diagnosis, early treatment strategies, and disposition options is crucial to the effective emergency department management of HIV infections and AIDS.

Disclaimer: This article is not intended to be a comprehensive review of all HIV-related disorders, particularly in light of the rapidly evolving diagnostic and therapeutic modalities available. Appropriate updated resources and infectious disease consultations should be sought whenever clinically indicated.