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Freshwater Metaviromics and Bacteriophages: A Current Assessment of the State of the Art in Relation to Bioinformatic Challenges
Evolutionary Bioinformatics
  • Katherine Bruder, Loyola University Chicago
  • Kema Malki, Loyola University Chicago
  • Alexandria Cooper, Loyola University Chicago
  • Emily Sible, Loyola University Chicago
  • Jason W Shapiro, Loyola University Chicago
  • Siobhan C Watkins, Loyola University Chicago
  • Catherine Putonti, Loyola University Chicago
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Publication Date
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Libertas Academica

Advances in bioinformatics and sequencing technologies have allowed for the analysis of complex microbial communities at an unprecedented rate. While much focus is often placed on the cellular members of these communities, viruses play a pivotal role, particularly bacteria-infecting viruses (bacteriophages); phages mediate global biogeochemical processes and drive microbial evolution through bacterial grazing and horizontal gene transfer. Despite their importance and ubiquity in nature, very little is known about the diversity and structure of viral communities. Though the need for culture-based methods for viral identification has been somewhat circumvented through metagenomic techniques, the analysis of metaviromic data is marred with many unique issues. In this review, we examine the current bioinformatic approaches for metavirome analyses and the inherent challenges facing the field as illustrated by the ongoing efforts in the exploration of freshwater phage populations.


Author Posting © Libertas Academica, 2016. This article is posted here by permission of Libertas Academica for personal use, not for redistribution. The article was published in Evolutionary Bioinformatics, Suppl 1, June 20, 2016,

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Creative Commons Attribution-No Derivative Works 3.0
Citation Information
Katherine Bruder, Kema Malki, Alexandria Cooper, Emily Sible, et al.. "Freshwater Metaviromics and Bacteriophages: A Current Assessment of the State of the Art in Relation to Bioinformatic Challenges" Evolutionary Bioinformatics Vol. Suppl 1 (2016)
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