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Article
Positional change in blood pressure and 8-year risk of hypertension: the CARDIA Study
Quantitative Health Sciences Publications and Presentations
  • Randal J. Thomas
  • Kiang Liu, Northwestern University
  • David R. Jacobs, University of Minnesota
  • Diane E. Bild
  • Catarina I. Kiefe, University of Massachusetts Medical School
  • Stephen B. Hulley, University of California
UMMS Affiliation
Department of Quantitative Health Sciences
Publication Date
8-13-2003
Document Type
Article
Subjects
Adolescent; Adult; African Americans; Blood Pressure; Cohort Studies; European Continental Ancestry Group; Female; Humans; Hypertension; Incidence; Logistic Models; Male; Posture; Risk Factors
Abstract
OBJECTIVE: To assess the relationship between positional blood pressure change and 8-year incidence of hypertension in a biracial cohort of young adults. SUBJECTS AND METHODS: Participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study with complete data from year 2 (1987-1988), year 5 (1990-1991), year 7 (1992-1993), and year 10 (1995-1996) examinations were included (N = 2781). Participants were classified into 3 groups based on their year 2 systolic blood pressure response to standing: drop, a decrease in systolic blood pressure of more than 5 mm Hg; same, a change of between -5 and +5 mm Hg; and rise, more than 5-mm Hg increase. RESULTS: The number of participants in each group was as follows: drop, 741; same, 1590; and rise, 450. The 8-year incidence of hypertension was 8.4% in the drop group, 6.8% in the same group, and 12.4% in the rise group (P < .001). Adjusted odds ratios for developing hypertension during the follow-up period in the rise group vs the same group were as follows: in black men, 2.85 (95% confidence interval [CI], 1.43-5.69), in black women, 2.47 (95% CI, 1.19-5.11), in white men, 2.17 (95% CI, 1.00-4.73), and in white women, 4.74 (95% CI, 1.11-20.30). CONCLUSIONS: A greater than 5-mm Hg increase in blood pressure on standing identified a group of young adults at increased risk of developing hypertension within 8 years. These findings support a physiologic link between sympathetic nervous system reactivity and risk of hypertension in young adults.
Source
Mayo Clin Proc. 2003 Aug;78(8):951-8.
PubMed ID
12911043
Related Resources
Link to Article in PubMed
Citation Information
Randal J. Thomas, Kiang Liu, David R. Jacobs, Diane E. Bild, et al.. "Positional change in blood pressure and 8-year risk of hypertension: the CARDIA Study" Vol. 78 Iss. 8 (2003) ISSN: 0025-6196 (Linking)
Available at: http://works.bepress.com/catarina_kiefe/92/