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Racial/ethnic disparities in patient-reported nonsteroidal antiinflammatory drug (NSAID) risk awareness, patient-doctor NSAID risk communication, and NSAID risk behavior
Quantitative Health Sciences Publications and Presentations
  • Rachel B. Fry, University of Alabama
  • Midge N. Ray, University of Alabama
  • Daniel J. Cobaugh
  • Norman W. Weissman, University of Alabama
  • Catarina I. Kiefe, University of Massachusetts Medical School
  • Richard M. Shewchuk, University of Alabama
  • Kenneth G. Saag, University of Alabama
  • Jeffrey R. Curtis, University of Alabama
  • Jeroan J. Allison, University of Massachusetts Medical School
UMMS Affiliation
Department of Quantitative Health Sciences
Publication Date
Document Type
African Americans; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Awareness; *Communication; Cross-Sectional Studies; European Continental Ancestry Group; Female; Gastrointestinal Diseases; Healthcare Disparities; Humans; Income; Male; Middle Aged; Odds Ratio; Patient Education as Topic; *Physician-Patient Relations; Rheumatic Diseases; Risk Factors; Risk-Taking

OBJECTIVE: Nonsteroidal antiinflammatory drugs (NSAIDs) are commonly used and frequently lead to serious adverse events. Little is known about NSAID-related ethnic/racial disparities. We focused on differences in patient NSAID risk awareness, patient-doctor NSAID risk communication, and NSAID risk-avoidance behavior.

METHODS: We performed a cross-sectional analysis of survey data from the Alabama NSAID Patient Safety Study. Eligible patients were > or = 65 years old and currently taking prescription NSAIDs (Rx NSAIDS). Generalized linear latent and mixed models accounted for nesting of patients within physicians.

RESULTS: Of all 404 participants, 32% were African American and 73% were female. The mean +/- SD age was 72.8 +/- 7.5 years, and 64% reported an annual household income <$20,000. African American patients were less likely than white patients to recognize any risk associated with over-the-counter (OTC) NSAIDs (13.3% versus 29.3%; P = 0.001) and Rx NSAIDs (31.3% versus 49.6%; P = 0.001), report that their doctor discussed possible NSAID-related gastrointestinal problems (38.0% versus 52.4%; P = 0.007), and take medications to reduce ulcer risk (30.5% versus 50.2%; P = 0.001). Patients with lower income and education reported significantly less risk awareness for OTC and Rx NSAIDs. Racial/ethnic differences persisted after adjusting for multiple confounders.

CONCLUSION: In this community-based study of low income elderly individuals receiving NSAIDs, we identified important racial/ethnic differences in risk awareness, communication, and behavior. Additional efforts are needed to promote safe NSAID use and reduce ethnic/racial disparities.

DOI of Published Version
Arthritis Rheum. 2007 Dec 15;57(8):1539-45. Link to article on publisher's site
PubMed ID
Related Resources
Link to Article in PubMed
Citation Information
Rachel B. Fry, Midge N. Ray, Daniel J. Cobaugh, Norman W. Weissman, et al.. "Racial/ethnic disparities in patient-reported nonsteroidal antiinflammatory drug (NSAID) risk awareness, patient-doctor NSAID risk communication, and NSAID risk behavior" Vol. 57 Iss. 8 (2007) ISSN: 0004-3591 (Linking)
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