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Cognitive change in heart failure: a systematic review
University of Massachusetts Medical School Faculty Publications
  • Alexandra M. Hajduk, University of Massachussetts Medical School
  • Catarina I. Kiefe, University of Massachusetts Medical School
  • Sharina D. Person, University of Massachusetts Medical School
  • Joel M. Gore, University of Massachusetts Medical School
  • Jane S. Saczynski, University of Massachusetts Medical School
UMMS Affiliation
Department of Quantitative Health Sciences; Department of Medicine, Divisions of Cardiovascular Medicine and Geriatric Medicine; Meyers Primary Care Institute
Publication Date
Document Type

BACKGROUND: Cognitive impairment, highly prevalent in patients with heart failure (HF), increases risk for hospitalization and mortality. However, the course of cognitive change in HF is not well characterized. The purpose of this systematic review was to examine the available evidence longitudinal changes in cognitive function in patients with HF.

METHODS AND RESULTS: A literature search of several electronic databases was performed. Studies published from January 1, 1980, to September 30, 2012, that used validated measures to diagnose HF and assess cognitive function >/=2x in adults with HF were eligible for inclusion. Change in cognitive function was examined in the context of HF treatments applied (eg, medication initiation, left ventricular assist device implantation), length of follow-up, and comparison group. Fifteen studies met eligibility criteria. Significant decline in cognitive function was noted among patients with HF followed up for >1 year. Improvements in cognition were observed among patients with HF undergoing interventions to improve cardiac function (eg, heart transplantation) and among patients examined over short time periods (year). Studies comparing patients' cognition over time with their own baseline tended to report improvements, whereas studies using a comparison group without HF tended to report declines or stability in cognition over time among patients with HF.

CONCLUSIONS: Patients with HF are at increased risk for cognitive decline, but this risk seems to be modifiable with cardiac treatment. Further research is needed to identify the mechanisms that cause cognitive changes in HF.

  • Cognition,
  • Epidemiology,
  • Heart failure
DOI of Published Version
Hajduk AM, Kiefe CI, Person SD, Gore JG, Saczynski JS. Cognitive change in heart failure: a systematic review. Circ Cardiovasc Qual Outcomes. 2013 Jul;6(4):451-60. doi: 10.1161/CIRCOUTCOMES.113.000121. Link to article on publisher's site

First author Alexandra M. Hajduk is a student in the Clinical and Population Health Research (CPHR) program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.

Related Resources
Link to Article in PubMed
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Citation Information
Alexandra M. Hajduk, Catarina I. Kiefe, Sharina D. Person, Joel M. Gore, et al.. "Cognitive change in heart failure: a systematic review" Vol. 6 Iss. 4 (2013) ISSN: 1941-7713 (Linking)
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