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Article
Relationship of early life stress and psychological functioning to adult C-reactive protein in the coronary artery risk development in young adults study
Quantitative Health Sciences Publications and Presentations
  • Shelley E. Taylor
  • Barbara J. Lehman
  • Catarina I. Kiefe, University of Massachusetts Medical School
  • Teresa E. Seeman, University of California
UMMS Affiliation
Department of Quantitative Health Sciences
Date
5-23-2006
Document Type
Article
Medical Subject Headings
Adult; Body Mass Index; C-Reactive Protein; Coronary Artery Disease; Databases, Factual; Family; Female; Humans; Male; Middle Aged; Risk Assessment; Socioeconomic Factors; Stress, Psychological
Abstract
BACKGROUND: Low socioeconomic status (SES) and a harsh family environment in childhood have been linked to mental and physical health disorders in adulthood. The objective of the present investigation was to evaluate a developmental model of pathways that may help explain these links and to relate them to C-reactive protein (CRP) in the Coronary Artery Risk Development in Young Adults (CARDIA) dataset. METHODS: Participants (n = 3248) in the CARDIA study, age 32 to 47 years, completed measures of childhood SES (CSES), early family environment (risky families [RF]), adult psychosocial functioning (PsyF, a latent factor measured by depression, mastery, and positive and negative social contacts), body mass index (BMI), and C-reactive protein. RESULTS: Structural equation modeling indicated that CSES and RF are associated with C-reactive protein via their association with PsyF (standardized path coefficients: CSES to RF, RF to PsyF, PsyF to CRP, CSES to CRP, all p < .05), with good overall model fit. The association between PsyF and CRP was partially mediated by BMI (PsyF to BMI, BMI to CRP, both p < .05). CONCLUSIONS: Low childhood SES and a harsh early family environment appear to be related to elevated C-reactive protein in adulthood through pathways involving psychosocial dysfunction and high body mass index.
Rights and Permissions
Citation: Biol Psychiatry. 2006 Oct 15;60(8):819-24. Epub 2006 May 19. Link to article on publisher's site
Related Resources
Link to Article in PubMed
Citation Information
Shelley E. Taylor, Barbara J. Lehman, Catarina I. Kiefe and Teresa E. Seeman. "Relationship of early life stress and psychological functioning to adult C-reactive protein in the coronary artery risk development in young adults study" Vol. 60 Iss. 8 (2006) ISSN: 0006-3223 (Linking)
Available at: http://works.bepress.com/catarina_kiefe/131/