Rural areas of the United States play a vital role in coping with, adapting to and mitigating climate change, yet they often lag urban areas in climate planning and action. Rural leaders—e.g., policymakers, state/federal agency professionals, non-profit organization leadership, and scholars – are pivotal for driving the programs and policies that support resilient practices, but our understanding of their perspectives on climate resilience writ large is limited. We conducted semi-structured interviews with 23 rural leaders in Missouri to elucidate their conceptualizations of climate resilience and identify catalysts and constraints for climate adaptation planning and action across rural landscapes. We investigated participants' perceptions of the major vulnerabilities of rural communities and landscapes, threats to rural areas, and potential steps for making rural Missouri more resilient in the face of climate change. We found that most rural leaders conceptualized climate resilience as responding to hazardous events rather than anticipating or planning for hazardous trends. The predominant threats identified were flooding and drought, which aligns with climate projections for the Midwest. Participants proposed a wide variety of specific steps to enhance resilience but had the highest agreement about the utility of expanding existing programs. The most comprehensive suite of solutions was offered by participants who conceptualized resilience as involving social, ecological, and economic systems, underscoring the importance of broad thinking for developing more holistic solutions to climate-associated threats and the potential impact of greater collaboration across domains. We highlight and discuss a Missouri-based levee setback project that was identified by participants as a showcase of collaborative resilience-building.