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Redox-Linked Conformation Change and Electron Transfer Between Monoheme C-Type Cytochromes and Oxides
Geochimica Et Cosmochimica Acta
  • N. Khare
  • D. M Lovelace
  • Carrick Eggleston, University of Wyoming
  • M. Swenson
  • T. S Magnuson
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Electron transfer between redox active proteins and mineral oxides is important in a variety of natural as well as technological processes, including electron transfer from dissimilatory metal-reducing bacteria to minerals. One of the pathways that could trigger electron transfer between proteins and minerals is redox-linked conformation change. We present electrochemical evidence that mitochondrial cytochrorne c (Mee) undergoes significant conformation change upon interaction with hematite and indiurn-tin oxide (ITO) surfaces. The apparent adsorption-induced conformation change causes the protein to become more reducing, which makes it able to transfer electrons to the hematite conduction band. Although Mcc is not a protein thought to be involved in interaction with mineral surfaces, it shares (or can be conformed so as to share) some characteristics with multiheme outer-membrane cytochromes thought to be involved in the transfer of electrons from dissimilatory iron-reducing bacteria to ferric minerals during respiration. We present evidence that a 10.1 kDa monohoeme cytochrorne isolated and purified from Acidiphilium cryptum, with properties similar to those of Mcc, also undergoes conformation change as a result of interaction with hematite surfaces. (c) 2006 Elsevier Inc. All rights reserved.
Citation Information
N. Khare, D. M Lovelace, Carrick Eggleston, M. Swenson, et al.. "Redox-Linked Conformation Change and Electron Transfer Between Monoheme C-Type Cytochromes and Oxides" Geochimica Et Cosmochimica Acta Vol. 70 Iss. 17 (2006) p. 4332 - 4342
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