![](https://d3ilqtpdwi981i.cloudfront.net/0nryMZR-Xd62FuSM_I8Y_uvbquI=/425x550/smart/https://bepress-attached-resources.s3.amazonaws.com/uploads/9a/85/c5/9a85c50e-ce1c-4edc-916a-43b66170f474/thumbnail_694b1aa5-a38d-47df-9794-00b42ca89be0.jpg)
Peptide hormones play a crucial role in body weight and glucose homeostasis. In this study, we aimed to explore this association and recruited 43 obese and 31 age-and sex-matched lean participants. We assessed their body mass index (BMI), waist circumference (WC), waist-to-height ratio (WtHR), percentage body fat (PBF), fasting blood levels of peptide hormones (GLP-1, GLP-2, insulin, leptin, ghrelin, CCK, and PYY), fasting blood sugar (FBS), and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). We tested the associations between peptide hormones and markers of obesity and insulin resistance (IR) by using the Independent-Samples t-test and Mann-Whitney U test, partial correlation, and logistic regression. FBS, insulin, HOMA-IR, GLP-1, GLP-2, and leptin were significantly higher in the obese group; ghrelin and CCK were significantly higher in lean participants, and no difference was seen for PYY. Controlling for BMI, GLP-1 was positively correlated with WtHR, while ghrelin was inversely correlated with WtHR. GLP-1 was correlated with HOMA-IR. GLP-1 was associated with obesity and IR markers in the regression model. Our results show that obese and lean adults display significant differences in plasma peptide hormone levels. GLP-1 levels were independently associated with markers of obesity and IR. Restoring the appetite hormone balance in obesity may represent a potential therapeutic target.
- Brain–gut axis,
- Cholecystokinin,
- Ghrelin,
- Glucagon-like peptide-1,
- Glucagon-like peptide-2,
- Insulin,
- Insulin resistance,
- Leptin,
- Obesity,
- Peptide yy
Available at: http://works.bepress.com/carole-ayoubmoubareck/18/