Introduction: since the first case of COVID-19 was confirmed in  February  2020,  Brazil  has  reported  more  than  20  million cases  and  more  than  600,000  deaths  on  October  31,  2021. 

The behavior of the pandemic was also different in the various states, from the less developed to the more developed, such as the state of São Paulo.

Objective: to describe step-by-step time series for analyzing trends in mortality, lethality and incidence of COVID-19 in Brazil.

Methods:  a  protocol  for  an  ecological  study  of  time  series, covering the 26 states and the federal district (Brasilia).

Results:   the   descriptions   have   the   potential   to   provide information for the government and society in decision-making about  knowledge  and  conduct,  clinical,  epidemiological  and research investments in health care services for the Brazilian people.  It  is 

 focused  on  fully  understanding  the  spread  of SARS-COV-2 infection in the Brazilian territory and developing a  database  for  public  and  universal  access  for  comparative studies between 

countries and continents.

Conclusion:   databases   built   from   ecological   studies   are essential  for  a  full  understanding  of  the  virus  behavior,  its transmissibility,  lethality  and  mortality,  and  a  repository  for data collected and integrated from multiple sources. They are relevant tools for the search of information and decision-making in global health.