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Association of Body Mass Index with Cardiovascular Disease Biomarkers
American Journal of Preventive Medicine (2015)
  • Paul D. Loprinzi, University of Mississippi
  • Carlos J. Crespo, Portland State University
  • Ross E. Andersen, McGill University
  • Ellen Smit, Oregon State University
Background: Few studies have examined the underweight–morbidity relationship, and those that have were conducted in non-U.S. populations and limited in their evaluation of cardiovascular disease (CVD) risk factors.
Purpose: To examine the associations among underweight (along with overweight and obese) and various CVD risk factors in a national sample of U.S. adults (aged ≥20 years).

Methods: Ten years of data (1999–2010) from the National Health and Nutrition Examination Survey were used (analyzed in 2014). Underweight (tertiles); overweight (25–29.9); and obesity (three classes: 30–34.9, 35–39.9, and ≥40) were assessed from measured BMI. The evaluated biological and anthropometric markers included waist circumference; mean arterial pressure; C-reactive protein (CRP); fasting low-density lipoprotein (LDL) cholesterol; total cholesterol; fasting triglycerides; and fasting glucose.

Results: After adjustments, underweight adults had significantly (p<0.005) lower levels of CRP (β=–0.12, Tertile 2); total cholesterol (β=–17.7 and –12.2, Tertiles 1 and 3); total cholesterol to high-density lipoprotein cholesterol ratio (β=–0.39 and –0.46, Tertiles 2 and 3); LDL cholesterol (β=–20.7, Tertile 1); and triglycerides (β=–37.1 and –18.0, Tertiles 1 and 3) compared to normal-weight individuals. The severely underweight and obese were less likely to be physically active than normal-weight adults (p<0.001). Adults in each of the overweight and obese groups had higher levels for each biomarker compared to normal-weight individuals.

Conclusions: Underweight adults have lower (i.e., more favorable) levels of various CVD biomarkers.
Publication Date
March, 2015
Citation Information
Paul D. Loprinzi, Carlos J. Crespo, Ross E. Andersen and Ellen Smit. "Association of Body Mass Index with Cardiovascular Disease Biomarkers" American Journal of Preventive Medicine Vol. 48 Iss. 3 (2015)
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