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About Carlo B. Bifulco, M.D.

Dr. Bifulco is a Surgical Pathologist with additional fellowship subspecialty training, expertise, and board certification in Molecular Genetic Pathology and Hematopathology. Dr. Bifulco currently serves as Chief Medical Officer, Providence Genomics, and as Member and Director of Translational Molecular Pathology and Molecular Genomics at the Earle A. Chiles Research Institute in Portland, Oregon, a division of Providence Cancer Institute. He oversees Providence Molecular Genomics Laboratory, one of the largest clinical genomics labs in the Pacific Northwest, which provides state-of-the-art genomic sequencing to cancer patients across the seven state PSJH system.
 
Prior to joining Providence, Dr. Bifulco served on the Pathology faculty at Yale University and completed fellowships in Oncologic Surgical Pathology and Molecular Genetic Pathology at Memorial Sloan Kettering Cancer Center. His current translational research is focused on supporting the characterization of the tumor immune microenvironment through immunohistochemical and image analysis techniques, and on the integration of genomics with immunotherapies. Dr. Bifulco serves on the Global Colon Cancer Immunoscore Task Force led by the Society for Immunotherapy of Cancer (SITC), and is Co-Chair of the SITC Pathology Task Force convened to establish multiplexed immunohistochemistry/ immunofluorescence (mIHC/IF) standards.

Positions

2019 - Present Medical Director, Providence ‐ Providence Molecular Genomics Laboratory
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2014 - Present Co-Lead, Providence ‐ Bioinformatics and Laboratory Pillars, Genomics Program
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2014 - Present Member and Medical Director, Providence ‐ Translational Molecular Pathology and Molecular Genomics, Providence Portland Medical Center, Portland, OR
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2008 - Present Attending, Providence Portland Medical Center ‐ Department of Pathology
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2011 - 2019 Director, Providence Portland Medical Center ‐ Molecular Pathology and Pathology Informatics, Dep. of Pathology
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2010 - 2012 NCCCP Biospecimens, Co-Lead, Providence Portland Medical Center ‐ Providence Cancer Center
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2006 - 2008 Director, Yale University ‐ Tissue Procurement and Banking Module, Department of Pathology
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2003 - 2007 Assistant Professor, Yale University ‐ Department of Pathology
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2003 - 2003 Assistant Professor, University of Florida ‐ Department of Pathology
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2001 - 2002 Director, National Cancer Institute, Milan, Italy ‐ Laboratory of Molecular Genetic Pathology, Department of Pathology
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2000 - 2002 Attending, National Cancer Institute, Milan, Italy ‐ Department of Pathology
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Disciplines

Grants

2020 - Present Developmental Research Program Grant: Machine-learning-based identification and quantification of immune cell content from multiplex immunofluorescence histopathology images in the neoadjuvant immunoradiotherapy (NIRT) cohort
Providence Cancer Institute
Role: Co-Investigator
2018 - Present Multispectral IHC to delineate the tumor environment in AML and monitor fluctuations with flotetuzumab
MacroGenics
Role: Co-Investigator
2018 - Present Understand the composition of immune cells in a tumor biopsy
Oncosec
Role: Co-Investigator
2020 - 2021 Applying machine learning techniques on routinely collected breast cancer data to improve patient outcomes
University of Chicago
Role: PI
2016 - 2020 Intra-Tumor IO: in vivo screening platform for Head and Neck Cancer
BMS
Role: Co-Investigator
2016 - 2019 Intra-tumoral pre-surgical IO
BMS
Role: Co-Investigator
2016 - 2018 Ipilimumab plus a galectin-3 inhibitor for metastatic melanoma
NIH - NIH R21 CA190790-01
Role: Co-Investigator
2015 - 2015 Development of "Immunoprofile" to direct therapy for OHNSCC
OMSF Research Support Grant (Fox)
Role: Co-PI
2010 - 2015 Mechanisms that Regulate Tumor-Specific Immune Response
NIH - NIH R01 CA080964
Role: Co-Investigator
2006 - 2007 Macrophage Migration Inhibitory factor (MIF) Polymorphisms in breast and gynecological malignancies
Ethel F. Donaghue Women's Health Investigator Program
Role: PI
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Education

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2007 - 2008 Fellow, Yale-New Haven Hospital ‐ Hematopathology
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1999 - 2000 Fellow, Memorial Sloan Kettering Cancer Center ‐ Molecular Genetic Pathology
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1998 - 1999 Fellow, Memorial Sloan Kettering Cancer Center ‐ Oncologic Pathology
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1996 - 1999 Resident, Yale-New Haven Hospital ‐ Anatomic Pathology
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1995 - 1996 Intern, Yale University ‐ Internal Medicine, Griffin Hospital
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1994 MD, State University of Milan, Italy
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Links

Research Works (131)