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A multicenter retrospective study of 151 renal biopsies in horses
Journal of Veterinary Internal Medicine (2011)
  • G A Tyner
  • R D Nolen-Walston
  • T Hall
  • J P Palmero
  • L Couetil
  • L Javsicas
  • A Stack
  • H Schott
  • A Johnson
  • L Hardefeldt
  • A Gruntman
  • Carla S. Sommardahl, University of Tennessee, Knoxville
  • N Menzies-Gow
  • P Depedro
  • T Norman
  • L C Fennell
  • J E Axon
  • S Lindborg
  • H Aceto
  • R Boston
  • J Engiles

BACKGROUND: Renal biopsies are uncommonly performed in horses and little is known about their diagnostic utility and associated complication rate. OBJECTIVE: To describe the techniques, the complication rate, risk factors, and histopathology results; as well as evaluate the safety and diagnostic utility of renal biopsy in the horse. ANIMALS: One hundred and forty-six horses from which 151 renal biopsies were obtained. Animals ranged in age from 48 hours to 30 years. METHODS: Multicenter retrospective study, with participation of 14 institutions (1983-2009). RESULTS: Renal biopsy in horses was associated with a similar rate of complications (11.3%) to that occurring in humans and companion animals. Complications were generally associated with hemorrhage or signs of colic, and required treatment in 3% of cases. Fatality rate was low (1/151; 0.7%). Biopsy specimens yielded sufficient tissue for a histopathologic diagnosis in most cases (94%) but diagnoses had only fair (72%) agreement with postmortem findings. Risk factors for complications included biopsy specimens of the left kidney (P = .030), a diagnosis of neoplasia (P = .004), and low urine specific gravity (P = .030). No association with complications was found for age, sex, breed, institution, presenting complaint, other initial clinicopathologic data, biopsy instrument, needle size, or use of ultrasonographic guidance. CONCLUSIONS AND CLINICAL IMPORTANCE: Renal biopsy in horses has low morbidity and results in a morphological histopathologic diagnosis in 94% of cases. However, this procedure might result in serious complications and should only be used when information obtained would be likely to impact decisions regarding patient management and prognosis.

Publication Date
Citation Information
G A Tyner, R D Nolen-Walston, T Hall, J P Palmero, et al.. "A multicenter retrospective study of 151 renal biopsies in horses" Journal of Veterinary Internal Medicine Vol. 25 Iss. 3 (2011)
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