Skip to main content
Article
Prefrontal regional correlates of self-control in male psychiatric patients: Impulsivity facets and aggression
Systems and Psychosocial Advances Research Center Publications and Presentations
  • David A. Gansler, Tufts University School of Medicine
  • Athene K. W. Lee, Suffolk University
  • Britt C. Emerton, Suffolk University
  • Christopher D'Amato, Lemuel Shattuck Hospital
  • Rafeeque A. Bhadelia, Tufts University School of Medicine
  • Matthew Jerram, Suffolk University
  • Carl E. Fulwiler, University of Massachusetts Medical School
UMMS Affiliation
Department of Psychiatry, Center for Mental Health Services Research
Date
1-30-2011
Document Type
Article
Medical Subject Headings
Adult; Aggression; Brain Mapping; Female; Humans; Image Processing, Computer-Assisted; Impulsive Behavior; Magnetic Resonance Imaging; Male; Mental Disorders; Middle Aged; Predictive Value of Tests; Prefrontal Cortex; Psychiatric Status Rating Scales; Regression Analysis; Sex Factors; Statistics as Topic
Abstract
Investigating the organization of trait aggression and impulsivity in the prefrontal cortex (PFC) advances our understanding of the neuropsychobiology of self-control. While the orbital aspect of the PFC (OFC) has received attention, there is reason to believe the lateral aspect is also relevant. In the current study using magnetic resonance imaging, gray matter volumes in lateral PFC (LPFC) were derived in a heterogeneous male psychiatric sample (N=36) in which OFC volumes had previously been reported. In an analysis using self-report measures of trait impulsivity and aggression, the left LPFC accounted for significant variance in attentional aspects of impulsivity (13%) and aggression (10%) but not motor aspects of impulsivity, as hypothesized. The OFC was associated with motor impulsivity (left-20%; right-14%) and was also more robustly associated with aggression (left-36%; right-16%). A social/emotional information processing model was explored, based upon whether the LPFC or the OFC depended upon one another for their association to trait aggression and impulsivity. It was demonstrated that association of the LPFC to both aggression and attentional impulsivity depended upon the OFC, while the converse was not supported. The LPFC appears relevant to the higher-order aspects of a cortical self-control network, and that relevance is dependent upon the robust contribution of the OFC.
Rights and Permissions
Citation: Psychiatry Res. 2011 Jan 30;191(1):16-23. Epub 2010 Dec 9. Link to article on publisher's website
Related Resources
Link to article in PubMed
PubMed ID
21145213
Citation Information
David A. Gansler, Athene K. W. Lee, Britt C. Emerton, Christopher D'Amato, et al.. "Prefrontal regional correlates of self-control in male psychiatric patients: Impulsivity facets and aggression" Vol. 191 Iss. 1 (2011) ISSN: 0165-1781
Available at: http://works.bepress.com/carl_fulwiler/25/