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A Comparison of Voxel-Based Morphometry and Volumetry Methods in the Context of the Neural Basis of Aggression
Systems and Psychosocial Advances Research Center Publications and Presentations
  • Britt C. Emerton, Suffolk University
  • Matthew Jerram, Suffolk University
  • Thilo Deckersbach, Harvard Medical School
  • Darin D. Dougherty, Harvard Medical School
  • Carl E. Fulwiler, University of Massachusetts Medical School
  • David A. Gansler, Tufts University School of Medicine
UMMS Affiliation
Department of Psychiatry
Publication Date
Document Type
Aggression; Frontal Lobe; Mental Disorders
The assumption that voxel-based morphometry (VBM) offers an automated substitution for manually-traced volumetry was subjected to empirical evaluation. Data available from a previous volumetry study (Gansler et al. Psychiatry Research: Neuroimaging 171:145–154, 2009) provided the basis for the current study, which assessed for convergence between the methods. Optimized modulated VBM was used to preprocess images (N  = 40). Gray matter volume and self-reported aggression associations were tested. Results indicate convergence, as both methods revealed significant negative associations of the left orbitofrontal cortex (OFC) and aggression. VBM detected an additional positive left OFC result not revealed with volumetry, suggesting that VBM may allow greater within-region localization than volumetry. However, the methods differentially deal with error rates and power demands and as such are better conceptualized as complementary than interchangeable.
  • Volumetry,
  • Voxel-based morphometry,
  • Orbital frontal cortex,
  • Aggression
DOI of Published Version
Emerton, B.C., Jerram, M., Deckersbach, T., Dougherty, D.D., Fulwiler, C., Gansler, D.A. A comparison of voxel-based morphometry and volumetry methods in the context of the neural basis of aggression. Brain Imaging and Behavior, Published online July 1, 2009 (DOI: 10.1007/s11682-009-9075-2).
Citation Information
Britt C. Emerton, Matthew Jerram, Thilo Deckersbach, Darin D. Dougherty, et al.. "A Comparison of Voxel-Based Morphometry and Volumetry Methods in the Context of the Neural Basis of Aggression" Vol. 3 Iss. 4 (2009)
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