Apparent neuroleptic malignant syndrome with clozapine and lithiumSystems and Psychosocial Advances Research Center Publications and Presentations
UMMS AffiliationDepartment of Psychiatry
Medical Subject HeadingsAdult; Bipolar Disorder; Clozapine; Dibenzazepines; Drug Therapy, Combination; Fluphenazine; Humans; Lithium; Lithium Carbonate; Male; Neuroleptic Malignant Syndrome
AbstractClozapine is an antipsychotic drug reported to be virtually free of extrapyramidal effects. On the basis of this, we hypothesized that it would be unlikely to cause the neuroleptic malignant syndrome (NMS), a rare but severe reaction observed with other antipsychotic drugs. However, when we administered clozapine (in conjunction with lithium) to a patient with a past history of NMS with fluphenazine, the syndrome reappeared after about 3 weeks of treatment. This represents, to our knowledge, the first report of apparent NMS with clozapine.
Rights and PermissionsCitation: J Nerv Ment Dis. 1986 Aug;174(8):493-5.
Related ResourcesLink to Article in PubMed
Citation InformationHarrison G. Pope, J. O. Cole, P. T. Choras and Carl E. Fulwiler. "Apparent neuroleptic malignant syndrome with clozapine and lithium" Vol. 174 Iss. 8 (1986) ISSN: 0022-3018 (Linking)
Available at: http://works.bepress.com/carl_fulwiler/12/