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Article
Cholecystokinin-immunoreactive innervation of the ventromedial hypothalamus in the rat: possible substrate for autonomic regulation of feeding
Systems and Psychosocial Advances Research Center Publications and Presentations
  • Carl E. Fulwiler
  • Clifford B. Saper, Washington University School of Medicine
UMMS Affiliation
Department of Psychiatry
Date
2-4-1985
Document Type
Article
Medical Subject Headings
Animals; Autonomic Nervous System; Feeding Behavior; Fluorescent Antibody Technique; Male; Neural Pathways; Pons; Rats; Rats, Inbred Strains; Sincalide; Ventromedial Hypothalamic Nucleus
Abstract

Cholecystokinin octapeptide (CCK) injected into the medial hypothalamus of the rat has been reported to suppress feeding. In this species, the superior lateral parabrachial subnucleus, which predominantly innervates the ventromedial nucleus of the hypothalamus, is composed primarily of CCK-immunoreactive neurons. Combined retrograde tracing using fluorescent dyes and immunofluorescence for CCK confirms that 80-90% of the neurons in the superior lateral parabrachial nucleus which innervate the ventromedial nucleus of the hypothalamus are CCK-positive. This pathway may underlie autonomic regulation of feeding behavior.

Rights and Permissions
Citation: Neurosci Lett. 1985 Feb 4;53(3):289-96.
Related Resources
Link to Article in PubMed
PubMed ID
3885078
Citation Information
Carl E. Fulwiler and Clifford B. Saper. "Cholecystokinin-immunoreactive innervation of the ventromedial hypothalamus in the rat: possible substrate for autonomic regulation of feeding" Vol. 53 Iss. 3 (1985) ISSN: 0304-3940 (Linking)
Available at: http://works.bepress.com/carl_fulwiler/11/