Cholecystokinin-immunoreactive innervation of the ventromedial hypothalamus in the rat: possible substrate for autonomic regulation of feedingSystems and Psychosocial Advances Research Center Publications and Presentations
UMMS AffiliationDepartment of Psychiatry
Medical Subject HeadingsAnimals; Autonomic Nervous System; Feeding Behavior; Fluorescent Antibody Technique; Male; Neural Pathways; Pons; Rats; Rats, Inbred Strains; Sincalide; Ventromedial Hypothalamic Nucleus
AbstractCholecystokinin octapeptide (CCK) injected into the medial hypothalamus of the rat has been reported to suppress feeding. In this species, the superior lateral parabrachial subnucleus, which predominantly innervates the ventromedial nucleus of the hypothalamus, is composed primarily of CCK-immunoreactive neurons. Combined retrograde tracing using fluorescent dyes and immunofluorescence for CCK confirms that 80-90% of the neurons in the superior lateral parabrachial nucleus which innervate the ventromedial nucleus of the hypothalamus are CCK-positive. This pathway may underlie autonomic regulation of feeding behavior.
Rights and PermissionsCitation: Neurosci Lett. 1985 Feb 4;53(3):289-96.
Related ResourcesLink to Article in PubMed
Citation InformationCarl E. Fulwiler and Clifford B. Saper. "Cholecystokinin-immunoreactive innervation of the ventromedial hypothalamus in the rat: possible substrate for autonomic regulation of feeding" Vol. 53 Iss. 3 (1985) ISSN: 0304-3940 (Linking)
Available at: http://works.bepress.com/carl_fulwiler/11/