Smoking is a preventable behavior that contributes to substantial loss of life and productivity. Although a growing amount of literature examines smoking among Asian American adolescents, there is a paucity of research investigating experiences that may contribute to smoking among Asian American adults. The purpose of this study is to investigate the links between life transitions and current smoking status among Asian American adults. A sample of Asian Americans was drawn from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) data set collected in 2001–2002 (Grant & Dawson, 2006). Results from logistic regressions indicate that after controlling for sex, age, income, proportion of life in the U.S., and ethnicity, life transitions in the past 12 months (i.e., interpersonal difficulties, death or illness of important other, divorce or separation, unemployment and occupational transitions) were found to be associated with increased odds of current smoking. Culturally specific prevention that centers around coping with stressful life transitions may help reduce smoking and its long-term consequences.