Semicoherent interfaces containing discrete dislocations are more energetically favorable than those containing continuous distributions because of lower chemical energy. The classical Frank-Bilby theory provided a way to determin. The interface Burgers vectors content but could not effectively predic. The characteristics of discrete dislocations. Atomistic simulations provide insights into analyzin. The characteristics of discrete dislocations bu. The analysis is often disturbed b. The reaction of interface dislocations. By combinin. The classical Frank-Bilby theory and atomistic simulations, an atomically informed Frank-Bilby theory proposed in this work can overcome shortcomings in bot. The classic Frank-Bilby theory and atomistic simulations, and enable quantitative analysis of interface dislocations. The proposed method has been demonstrated via studying two typical dissimilar metallic interfaces. The results showed that Burgers vectors of interface dislocations can be well defined in a Commensurate/Coherent Dichromatic Pattern (CDP) an. The Rotation CDP (RCDP) lattices. Most importantly. The CDP and RCDP lattices are not simply a geometric average o. The two natural lattices, that i. The lattice misfit an. The relative twist tak. The nonequal partition o. The misfit strain an. The twist angle.