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Cognitive Event-Related Potentials in Young Adults With Cerebral Palsy: A Proof-of-Concept Study
Clinical EEG and Neuroscience
  • Christine L. Lackner, Brock University
  • Jan Willem Gorter, CanChild Centre for Childhood Disability Research
  • Sidney J. Segalowitz, Brock University
  • Sarah Hopmans
  • Julie Wilson
  • Helena Viveiros
  • John Secen
  • Paul Stacey
  • Caitlin Cassidy
  • Diana Parvinchi
  • Sophia Roth
  • Darcy Fehlings
  • Mark Ferro
  • Andrea Gonzalez
  • Geoffrey Hall
  • Anna McCormick
  • Robert Palisano
  • Peter Rosenbaum
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Cerebral palsy (CP) is a movement and posture disorder often accompanied by cognitive difficulties which can be assessed using event-related potentials (ERPs), an often-overlooked tool in this population. Here we describe our assessment protocol, examine its feasibility, and validate the use of single-subject ERP analyses in adolescents and young adults with CP, an analysis approach which recognizes the heterogeneity of the clinical population. This study involved a final sample of 9 adolescents/young adults with CP participating in the “MyStory” study (age range 16-29 years, Mage = 25.0 years; 6 female; Gross Motor Function Classification System level I [n = 4], II [n = 2], III [n = 1], IV [n = 1], and V [n = 1]). ERP components were elicited over medial prefrontal and central cortex (error- and correct-related negativities [ERN/CRN], error-positivity [Pe], N100, P200, N200, P300), as well as those generated over occipital cortex (P100, N170). Group and single-subject ERP statistics were computed for ERPs recorded over both areas. Using recently developed data analysis methods (independent components analysis and robust bootstrapped single-subject statistics), we measured the number of participants demonstrating significant condition differences at the timing of each ERP component of interest. We demonstrate good validity for ERPs recorded during 2 of our 3 tasks eliciting frontal activation (eg, 4 of 6 participants with usable data showed a significant single-subject medial frontal negativity condition difference in a context-switching task) and good validity for ERPs derived from a task engaging occipital regions (eg, 8 of 9 participants each showed a significant N170 face-object condition effect).

Citation Information
Christine L. Lackner, Jan Willem Gorter, Sidney J. Segalowitz, Sarah Hopmans, et al.. "Cognitive Event-Related Potentials in Young Adults With Cerebral Palsy: A Proof-of-Concept Study" Clinical EEG and Neuroscience (2020)
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