Marital health advantages and the increase of interracial marriage (intermarriage) are well documented, but few studies investigate the health of intermarried people. We address this issue using aggregated data from the 2000–2013 Current Population Survey (CPS) and find that people with racial/ethnic minority spouses report lower self-rated health than those married to whites. Spousal race significantly moderated the association between respondent’s race and self-rated health such that minorities in same-race marriages had lower odds of reporting better health than those intermarried to whites. However, we found no differences in self-rated health among minorities intermarried to other minorities. There was also limited evidence that gender and socioeconomic status (SES) moderated the interaction between respondent’s race and spousal race. Our findings highlight the effects of marriage on the self-rated health of respondents and their spouse as well as the importance of examining differences in couple’s racial composition when investigating racial disparities in spousal health.