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Article
Statistical Models for Assessing Agreement in Method Comparison Studies with Replicate Measurements
The International Journal of Biostatistics (2009)
  • Bendix Carstensen, Steno Diabetes Center
  • Julie Simpson, University of Melbourne
  • Lyle C Gurrin, University of Melbourne
Abstract

Method comparison studies are usually analyzed by computing limits of agreement. It is recommended that replicate measurements be taken by each method, but the resulting data are more cumbersome to analyze. We discuss the statistical model underlying the classical limits of agreement and extend it to the case with replicate measurements. As the required code to fit the models is non-trivial, we provide example computer code to fit the models, and show how to use the output to derive measures of repeatability and limits of agreement.

Keywords
  • method comparison,
  • Bland-Altman plot,
  • mixed models
Publication Date
January 5, 2009
Citation Information
Bendix Carstensen, Julie Simpson and Lyle C Gurrin. "Statistical Models for Assessing Agreement in Method Comparison Studies with Replicate Measurements" The International Journal of Biostatistics Vol. 4 Iss. 1 (2009)
Available at: http://works.bepress.com/bxc/1/