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Article
Interferonγ /IL10 ratio defines the disease severity in pulmonary and extra pulmonary tuberculosis
Tuberculosis
  • Bushra Jamil, Aga Khan University
  • Firdaus Shahid, Aga Khan University
  • Zahra Hasan, Aga Khan University
  • Nosheen Nasir, Aga Khan University
  • Tashmeem Razzaki, University of Karachi
  • Ghaffar Dawood, Masoomeen General Hospital, Karachi
  • Rabia Hussain, Aga Khan University
Publication Date
1-1-2007
Document Type
Article
Abstract
Several cytokines (IFNγ, TNFα, IL10 and IL6) show an association with either disease localization or dissemination in tuberculosis. There are also reports of involvement of extra-pulmonary sites in tuberculosis with differential clinical severity. However, no comparative study of biomarkers across the disease severity spectrum is available. This was the purpose of the current study. Cytokines (IFNγ, TNFα, IL10 and IL6) secreted in response to a panel of stimulants (PHA, LPS or mycobacterial antigens) in whole blood were determined in eighty-two tuberculosis patients. WHO criteria was applied for stratification of patients according to disease severity: disseminated and or severe disease (EPTB1; N=29); disease localized to lung parenchyma (PTB; N=32) and disease localized to peripheral sites without lung involvement (EPTB2; N=21). Mycobacterial antigens induced IFNγ/IL10 ratio showed a direct relationship with disease severity ranking (median ratios: EPTB1=0.21; PTB=0.85; EPTB2=7.7) and the highest correlation (Spearman Rank; rho=0.673, p<0.000001). IFNγ/IL10 ratio also rank ordered clinical severity as it relates to anatomic sites. IFNγ/IL10 ratio may therefore provide a useful objective marker of disease severity in both pulmonary and extra-pulmonary tuberculosis.
Citation Information
Bushra Jamil, Firdaus Shahid, Zahra Hasan, Nosheen Nasir, et al.. "Interferonγ /IL10 ratio defines the disease severity in pulmonary and extra pulmonary tuberculosis" Tuberculosis Vol. 87 Iss. 4 (2007) p. 279 - 287
Available at: http://works.bepress.com/bushra_jamil/39/