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Tricyclic Antidepressant Toxicity Treated With Massive Sodium Bicarbonate
The American Journal Of Emergency Medicine
  • Kathleen E Kane, MD, Lehigh Valley Health Network
  • Bryan G Kane, MD, Lehigh Valley Health Network
  • Jessica E Pierog, DO, Lehigh Valley Health Network
  • J Ward Donovan, PinnacleHealth Toxicology CenterPennsylvania State UniversityHarrisburg Hospital, Harrisburg, PA
  • Tracey Helmick, RN, Harrisburg Hospital, Harrisburg, PA
Publication/Presentation Date
Tricyclic antidepressant (TCA) morbitity is primarily due to cardiac arrhythmias and hypotension, which become more refractory to treatment as acidosis progresses (Ann Emerg Med. 1985;14:1-9; Clin Toxicol. 2007;45:203-233; Flomenbaum N, Goldfrank L, Hoffman R, et al. Goldfrank's toxicologic emergencies. 8th ed. McGraw-Hill Companies, Inc, 2006). Early recognition and aggressive treatment are necessary for patient survival.
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Citation Information

Pierog, J. E., Kane, K. E., Kane, B. G., Donovan, J. W., & Helmick, T. (2009). Tricyclic antidepressant toxicity treated with massive sodium bicarbonate. The American Journal Of Emergency Medicine, 27(9), 1168.e3-7. doi:10.1016/j.ajem.2008.11.026.