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Article
Tricyclic Antidepressant Toxicity Treated With Massive Sodium Bicarbonate
The American Journal Of Emergency Medicine
  • Kathleen E Kane, MD, Lehigh Valley Health Network
  • Bryan G Kane, MD, Lehigh Valley Health Network
  • Jessica E Pierog, DO, Lehigh Valley Health Network
  • J Ward Donovan, PinnacleHealth Toxicology CenterPennsylvania State UniversityHarrisburg Hospital, Harrisburg, PA
  • Tracey Helmick, RN, Harrisburg Hospital, Harrisburg, PA
Publication/Presentation Date
11-1-2009
Abstract
Tricyclic antidepressant (TCA) morbitity is primarily due to cardiac arrhythmias and hypotension, which become more refractory to treatment as acidosis progresses (Ann Emerg Med. 1985;14:1-9; Clin Toxicol. 2007;45:203-233; Flomenbaum N, Goldfrank L, Hoffman R, et al. Goldfrank's toxicologic emergencies. 8th ed. McGraw-Hill Companies, Inc, 2006). Early recognition and aggressive treatment are necessary for patient survival.
PubMedID
19931778
Document Type
Article
Citation Information

Pierog, J. E., Kane, K. E., Kane, B. G., Donovan, J. W., & Helmick, T. (2009). Tricyclic antidepressant toxicity treated with massive sodium bicarbonate. The American Journal Of Emergency Medicine, 27(9), 1168.e3-7. doi:10.1016/j.ajem.2008.11.026.