The apolipoprotein E4 (apoE4) genotype is a major risk factor for developing late-onset Alzheimer’s disease (AD). Inheritance of apoE4 is also associated with impairments in olfactory function in early stages of AD. In this project we examined the effects of the three common isoforms of human apoE (apoE2, apoE3, and apoE4) on neuronal differentiation and neurite outgrowth in explant cultures of mouse olfactory epithelium (OE).
- Neurite outgrowth,
- Neuronal differentiation,
- Olfactory neurons,
- Low-density lipoprotein receptor-related protein,
- Receptor-associated protein,
- Alzheimer’s disease
Available at: http://works.bepress.com/britto_nathan/1/