Article
Structures of thrombospondins [Review]
Cellular and Molecular Life Sciences
(2008)
Abstract
Thrombospondins are large secreted, multimodular, calcium-binding glycoproteins that have complex roles in mediating cellular processes. Determination of high-resolution structures of thrombospondins has revealed unique and interesting protein motifs. Here, we review this progress and discuss implications for function. By combining structures of modules from thrombospondins and related extracellular proteins it is now possible to prepare an overall model of the structure of thrombospondin-1 and thrombospondin-2 and discern features of other thrombospondins. (Part of a multi-author Review)
Keywords
- Thrombospondin,
- extracellular protein structure,
- cartilage oligomeric matrix protein,
- calcium
Disciplines
Publication Date
March, 2008
DOI
10.1007/s00018-007-7484-1
Citation Information
C. Britt Carlson, Jack Lawler and Deane F. Mosher. "Structures of thrombospondins [Review]" Cellular and Molecular Life Sciences Vol. 65 Iss. 5 (2008) p. 672 - 686 ISSN: 1420-682X (print) 1420-9071(online) Available at: http://works.bepress.com/britt-carlson/7/