This report provides an assessment of the feasibility of developing an aerotropolis around Cleveland Hopkins International Airport, Cleveland, Ohio. The report describes the methodology used to assess the feasibility, notes the needs and expectations of community stakeholders, profiles the challenges and successes of six emerging and potential U.S. aerotropolises, and discusses the operating experiences and challenges of 12 additional U.S. airports. Further, this report describes the demographic and economic aspects of the study cities, and discusses potential target industry opportunities. The findings suggest that it is feasible to develop CLE as an aerotropolis, and that CLE may not be suited for an aerotropolis as practiced at other domestic and international airports. Rather, the concept itself may be the platform for moving forward with a defined, staged strategy for development surrounding CLE and should be viewed as an opportunity to develop the concept to specifically fit the region and its economic circumstance.